flipper44,
Excellent response. There is one other thing that I have been thinking about and that is that with L T-cells and others are drawn to signaling from dead and dying cells and follow the path that leads to them. Not every part of the remaining tumor will be damaged, though, especially in unmethylated patients after 3 months and if there are enough surrounding normal cells covering existing tumor cells and inflammatory signaling not strong enough for cancer antigens to be exposed in response to a strong pro inflammatory response, those T-cells will move right past the cancer cell clusters. The counter balance is the greater number of targets in mesenchymal genotype and phenotype that allows for a slowdown of advance because some antigens are exposed in transition. We know methylated mesenchymal creates the best opportunity for L to work as well as suspect that earliest intervention in unmethylated mesenchymal patients is best for that patient population. Direct creates a pro inflammatory response in the tumor environment under the right conditions and that creates an ongoing susceptibility to attack as long as DC signaling is properly maintained. Best wishes.
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