Replies to post #322648 on Anavex Life Sciences Corp (AVXL)

[Kentucky123]

Here is an AVXL related article.


https://www.stockgumshoe.com/2021/07/alzheimers-in-2021-plus-ca-change-plus-cest-le-meme-chose/

Here he talks about 2-73 and some other stuff.


https://www.stockgumshoe.com/2021/06/responses-to-questions-and-selected-news-items/

[nidan7500]

Thanks falconer, I was hoping you would say that.

Are SAVA and AVXL on similar but different paths?

falconer

very different mechanisms of action. Cassava’s simufilam favorably reconfigures just one particular protein, filamin A, which may indeed help suppress Alzheimer’s. But for other CNS diseases, doubtful.

Falconer

And, very different mechanisms of action. Cassava’s simufilam favorably reconfigures just one particular protein, filamin A, which may indeed help suppress Alzheimer’s. But for other CNS diseases, doubtful.

In summary, Cassava and Anavex, while both targeting Alzheimer’s, are on very differing “pathways.” I’ll go with Anavex. Their drug, blarcamesine, causes the cell (neurons) to properly configure, fold, a diversity of “downstream-acting” proteins (primarily, enzymes) which then healthfully normalize a diversity of cellular functions; not the least of which is autophagy, the ability of the cell to consume and reprocess chemical wastes (such as the protein wastes, beta-amyloid and tau clusters) that apparently cause or contribute to Alzheimer’s.

[Pazzo1212]

So a follow up question is could they be synergistic?