Replies to post #97 on MyMD Pharmaceuticals Inc (MYMD)

[leifsmith]

I saw for myself the benefits of anatabine citrate among friends credibly approaching the status of human.

Nevertheless, you make a good point.

I like the brevity and topicality of the planned trial. Its results should allow speculative generalization to a huge range of diseases that would require longer trials.

I expect the results to be good, and that scientific speculation will translate into increased stock price.

[leifsmith]

Evidence of human benefit of nicotinic molecule, 2012

knuts4oe wrote:

we have yet to see the 1st scientific evidence that the nicotinic molecules have any human medical benefits

https://pubmed.ncbi.nlm.nih.gov/22807490/

This study involves some of the same Johns Hopkins scientists, e.g., Patrizio Caturegli, who are currently working with MYMD1, another alkaloid molecule (almost identical to anatabine citrate in structure)

From the above paper (my highlight):

Tobacco smoking favorably influences the course of Hashimoto thyroiditis, possibly through the antiinflammatory proprieties of nicotine. In this study we tested anatabine, another tobacco alkaloid, in a model of experimental autoimmune thyroiditis.

and

Tobacco smoking has numerous detrimental effects on human health, but it has also been associated with a few apparent salutary actions, including the amelioration of autoimmune (Hashimoto) thyroiditis and ulcerative colitis. Smokers in the Third National Health and Nutrition Examination Survey were found to have lower prevalence of thyroperoxidase and/or thyroglobulin antibodies than nonsmokers (1). This protective effect of smoking was confirmed in two additional cross-sectional studies, one from the Amsterdam autoimmune thyroid disease cohort (2) and the other from the Danish population (3), as well as in a 5-yr prospective study also based on the Amsterdam autoimmune thyroid disease cohort (4). In the prospective study, cigarette smoking women who had one or more relative with documented thyroid autoimmunity but no thyroid dysfunction or autoantibodies at study entry showed lower odds of developing thyroperoxidase and/or thyroglobulin antibodies (4). Similarly in ulcerative colitis, smoking has been shown to decrease flares (5), hospitalizations (6), and a need for oral glucocorticoids (7) so that low-dose smoking resumption has been successfully used in ex-smokers with refractory disease (8).