Penny, are you speculating that Dr Missling is going to include the ole into the final results we get Monday? The placebo group have been on the drug for some time now. How powerful would that be to show the reversal of placebo, almost like a fourth arm of the trial. I still wonder about the 30 and 50 mg arms. I know the patients are titrated up but what if the get dizzy at 50 mg or 30 mg, are they allowed to back off the drug mg a bit until comfortable or do they just discontinue the trial? One thing is for certain and that is in the OLE Im sure they get the optimized dose!