Yes, as surely many are, I am in that good situation too and could decide to just ride it out knowing that I can't lose.
Still though, I would hate to see the increase in gain now potentially being wiped out. My experience, as in my example earlier today, tells me that the next and long awaited Rett and PDD data does come with a chance of being less great than we all hope.
In this situation I continue to balance might portfolio, although for a stock like $AVXL at this point with overweight.