Replies to post #342575 on Amarin Corp Plc (AMRN)

[iryokabu]

Let's say AA level is the same in R-IT and STRENGTH, and AA=50. (I assume that DHA would not affect EPA level or AA level).

EPA/AA ratio: (We don't know exact number)
- Placebo in both trials: 25/50 = 0.5
- Strength: 90/50 = 1.8 (follow up study recently published in JAMA cardiology: 120/50 =2.4)
- R-IT: 150/50 = 3

In STRENTH trial, even EPA/AA level 3-5 time higher than placebo, there was no CVD benefit. That is why we (including you?) are thinking DHA is inhibiting the effect of EPA. I think the higher DHA level is, the more it is inhibiting EPA effect.