Thanks flip, I didn’t know that. When I received their response, I assumed the Mayo Clinic manufactured it in one of their labs. I'm sure it's why NW Bio continues to fight for those patents!
MAYO CLINIC HUMAN CELLULAR THERAPY LABORATORIES Cell therapy, which uses specific types of stem cells to repair damaged tissues, is one approach in the regenerative medicine toolkit. The Center for Regenerative Medicine works closely with the Human Cellular Therapy Laboratories to develop and produce safe cellular products for research and patient care purposes.
With locations at Mayo Clinic's campuses in Minnesota, Florida and Arizona, the Human Cellular Therapy Laboratories include scientists, regulatory specialists and laboratory technologists with expertise in cell biology, protocol development, clinical trial monitoring and the regulatory environment.
The Human Cellular Therapy Laboratories are compliant with current good manufacturing practice (CGMP) regulations as they apply to cell manufacturing.
Regenerative medicine applications Development of regenerative cellular therapies is underway in the Human Cellular Therapy Laboratories for more than a dozen conditions. For each disease, the cellular product is being made from the patient, for the patient — the patient's own cells are being expanded or activated to treat his or her specific disease.
In nearly all cases, these regenerative therapies are intended for people for whom there are no other treatment options available.
Cellular therapies are in development for: * Heart attack (acute myocardial infarction) * Amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease) * Anal fistulas * Brain cancer * Breast cancer * Critical limb ischemia * Degenerative disk disease * Diabetes * Hypoplastic left heart syndrome * Intracranial saccular aneurysms * Liver repair and tolerance induction * Lymphoma * Osteoarthritis * Ovarian cancer * Renal stenosis * Stage IV glioblastoma * Stroke
In addition to supporting the Center for Regenerative Medicine, the Human Cellular Therapy Laboratories provide cellular products for bone marrow transplants, the Mayo Clinic Cancer Center, the Division of Transfusion Medicine and individual Mayo Clinic investigators.
CANCER RESEARCH AND CELLULAR THERAPIES: JANUARIO E. CASTRO
* Taking cellular therapies to the next level Our lab is advancing new therapies and improving existing therapies for hematological cancers and solid tumors.
* Developing new targets One main focus of our lab is developing new therapeutic targets for pancreatic cancer and breast cancer using chimeric antigen receptor (CAR)-T cells.
* Harnessing artificial intelligence We're applying artificial intelligence and machine learning models to immuno-oncology.
OVERVIEW Under the direction of principal investigator Januario E. Castro, M.D., the Cancer Research and Cellular Therapies Laboratory studies advanced cellular therapies for cancer, with a particular emphasis on hematological malignancies. Our lab also collaborates on research projects involving solid tumors.
The mission of the Cancer Research and Cellular Therapies Lab is to take cellular therapies to the next level.
Our lab is working to improve existing cancer treatments, such as chimeric antigen receptor (CAR)-T cell therapy, and investigating new treatment targets, including alternative splicing mechanisms and epitope spreading.
Our laboratory aims to improve clinical outcomes and patient care through collaborative efforts both at Mayo Clinic and other institutions and through the application of translational research, moving our findings from the lab to the clinic.
Special areas of research interest include: * Cellular therapy * Immunotherapy * Acute and chronic leukemias * Lymphomas * Myeloma * Translational hematology and oncology
The Cancer Research and Cellular Therapies Lab is based at Mayo Clinic's campus in Phoenix, Arizona.
About Dr. Castro In addition to acting as the lab's principal investigator, Dr. Castro is the director of the Adoptive Cellular Therapy CAR-T Cell Program at Mayo Clinic in Arizona. Dr. Castro's research focuses on hematological malignancies and on developing new targets for CAR-T cell therapies. He's also involved in the Mayo Clinic Enterprise Cellular Therapy Biobank and the Mayo Clinic Cancer Registry. As a senior associate consultant in hematology and oncology, Dr. Castro also treats patients at Mayo Clinic.
RESEARCH PROJECTS Research in the Cancer Research and Cellular Therapies Laboratory includes the development of potential cellular therapies that target primary and metastatic tumors using advanced technologies and improvements in care for patients undergoing cancer treatment.
Our lab has several ongoing research projects led by Dr. Castro, including these projects: * Cellular therapy for hematological cancers. Our lab has extensive experience conducting leading-edge research and clinical trials in cellular therapy. Our goal is to develop better, more patient-friendly therapies for different cancers, including acute and chronic leukemias and lymphomas.
* Cellular therapy for solid tumors. In collaboration with Mitesh J. Borad, M.D., and Karen S. Anderson, M.D., Ph.D., both physicians at Mayo Clinic in Phoenix, Arizona, we're working to develop new therapeutic targets for pancreatic cancer and breast cancer using chimeric antigen receptor (CAR)-T cells and exploring new ways to improve the efficacy of CAR-T cell therapy.
* Immune system response. Our lab is identifying novel markers at different time points during whole-cell therapy for hematological malignancies and solid tumors to help fight cancer with new mechanisms.
* Early detection of side effects. We're developing new biotechnologies to better monitor patients undergoing cellular therapies, with the goal of improving early detection and management of side effects to reduce hospital admissions.
* Artificial intelligence and machine learning models applied to immuno-oncology. Clinical prediction models are usually based on multiple variables, and sometimes it's not feasible to identify which characteristics discriminate better between two sets of patients. Machine learning is a subset of artificial intelligence techniques that can be defined as the scientific study that makes computers learn from data in order to discover knowledge from them. Machine learning also has the particular advantage of recognizing subtle patterns in complex data sets by creating a decision boundary known as a hyperplane.
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