Replies to post #381216 on NorthWest Biotherapeutics Inc (NWBO)

[The Danish Dude]

Do you still trust people even after they lie to you? Why?

You know why.

It is being carved in stone day after day by the best DD’ers on any stock bulletin boards.
All info during the last 7-8 months points to a success.
The blended data looks absolutely awesome.
The big fat tail shows it.

If you don’t trust NWBO or the results, then sell and find another play.

[marzan]

JR, how better is the PD-1 Keytruda or Opdivo immunotherapy Science compared to DcVaxL?? Honest opinion please. How comes these checkpoint inhibitors are bringing in so much revenue to those BPs who sell them? If the immunotherapy science is no good, are these CIs scams too??

[MI Dendream]

Much of what you say is food for thought...this however is not. It is misguided thinking clearly.

You can't just change the endpoints at the end of a 16-year trial and think everything will be hunky dory. That's not the way scientific study works. They have major, major problems with this trial. You know it, I know it, and everyone who has ever followed a bio-tech startup knows it.

I can go back and quote the relevant FDA guidelines again if you wish. When a study has placebo terminated, this tells you something critical. When FDA halts new screening short of the goal, but allows you to move forward with treatment in existing patients and in newly manufactured patients, this tells you something as well. When the integrity of a study design is destroyed by FDA rather than by the sponsor this tells you something more. What Linda Liau presented in Utah is scientific method regardless of your lay opinion. She remained blinded to treatment at the time the SAP was developed which is also consistent with FDA regs and scientific methods. This is not Post Hoc analysis. EMEA clearly proves you are wrong about this. My view is FDA’s hand has been visible for some time now. All the way back to the halt in placebo. Placebo was no longer ethical after DSM viewed safety data.

[JohnnyGalt]

Nice "straw man" argument.

You start by indicating that nobody has said that NWBO is a pump and dump (in fact you call it absurd) and then go onto ascribe the company management as perpetuating a long term "pump no dump" scheme to enrich themselves over time (equally absurd).

As evidence of this you make non-specific generalizations about management press releases and ask the ihub readers of your post to "look back" to past releases and timing. Here's a thought, if you want to accuse management of such a scheme how about you look back, do the research and present it in a reasoned argument?

To top it all off, it's particularly amusing that you mention starting an argument from a false premise (which is exactly how your post presents).

[IkeEsq]

See, here is the problem. You completely misidentify what most NWBO skeptics are saying. I'm not aware of anyone who has said NWBO is a "pump and dump" scheme. Why would anyone call a 16-year-old trial a pump and dump? Does that make any sense at all? No, it doesn't, so the fact is, you start your argument from a false premise.

For starters, they are not 'skeptics' they are trolls paid to trash NWBO on social media. You can't honestly say after the last 5 years in the U.S. that anyone could be unaware of the widespread use of such people on social media. And plenty of people have accused NWBO of running a pump and dump scheme, you included . . . right now.

I, and others, have speculated that NWBO from time to time has used certain public statements to pump the share price, usually right around the time of a cash raise, to allow lenders who have been paid in warrants an opportunity to quickly cash out at a nice short-term profit. The evidence is there, like it or not. Go back and look at statements made by the Investor Relations employee and the timing of those statements, especially his comment that an upcoming ASM would be so "interesting" we wouldn't want to miss it, and he and CEO encouraging shareholders to travel to the meeting from all over the world. These comments were highly unusual and, of course, the actual meeting presentation did not bear out any of the hype, while the comments led to a substantial share price rise coincidental with a cash raise. This has happened more than once.

No. If you want to accuse people in public, in writing, of committing large-scale, $millions in fraud, then YOU need to have a lot more than speculation. That is called libel. YOU need to dig out those press releases, document the before and after price and volume of the stock, document the number of warrants outstanding (and thus exercised), and look at the terms of the loans, most of which require the holders to delay exercise of the warrants for a specified time period, which completely nullifies your speculative theory.

But those were isolated incidents. Certainly NWBO's DCVax-L Phase 3 trial, taken as a whole, is not a pump and dump scheme. That's absurd.

. . .

NWBO is not a pump and dump,

Great, so someone is finally accepting the obvious. It is nice that we can agree on something.

The change of endpoints on a web site has no bearing on regulatory approval,

Ummm, yes, that is exactly how it works when it is the regulatory authority, which it is in the countries in which the end-points have been changed online, who are responsible for updating the website.

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Your contention is that NWBO figured out 5 years ago that the trial failed. If that were the case, then please explain how they pulled the wool over the eyes of the leading oncologists on the planet, including the one most associated with DC-Vax, Linda Liu? How is NWBO feeding them fraudulent data and misleading them about the success of the trial?