Replies to post #360000 on Innovation Pharmaceuticals Inc (IPIX)

[petemantx]

Do you really believe it will be an antiviral, anti-inflammatory, and have the immunotherapeutic properties that are needed for CV19 and which only Brilacidin seems to possess?

IMO we will see a nebulizer or nose/throat spray delivery system near the end of the year time frame for emergency applications of B.

From what I have seen BP over hypes and under delivers - don't see any reason for a change in this with the PFE pill.

[farrell90]

The Pfizer Covid19 drug is a protease inhibitor. All the protease inhibitors tested to date have failed to show efficacy against Covid19.

These include the antiviral drugs. lopinavir, ritonavir, darunavir andcobicistat have been shown in clinical trials to not be effective against Covid19.

The current FDA recommendation is to not use any protease inhibitor against Covid19 in any patient:

"Recommendations

The COVID-19 Treatment Guidelines Panel (the Panel) recommends against the use of lopinavir/ritonavir and other HIV protease inhibitors for the treatment of COVID-19 in hospitalized patients (AI).
The Panel recommends against the use of lopinavir/ritonavir and other HIV protease inhibitors for the treatment of COVID-19 in nonhospitalized patients (AIII)."

https://www.covid19treatmentguidelines.nih.gov/antiviral-therapy/lopinavir-ritonavir-and-other-hiv-protease-inhibitors/

In addition lopinavir and ritonavir have significant cardiac and hepatotoxicity

The Pfiizer study is a phase 1 ascending dose trial in 60 healthy volunteers. This is the first time the drug has been used in humans.

https://clinicaltrials.gov/ct2/show/study/NCT04756531#contacts