STIMULATION OF T REGULATORY CELLS BY CANNABIDIOL AS A MEANS OF TREATING ARTHRITIS AND AUTOIMMUNITY Publication number: 20210059962 Abstract: Disclosed are means, methods, and compositions of matter for stimulation of T regulatory (Treg) cells by cannabidiol. In one embodiment, administration of cannabidiol is performed in an animal suffering from autoimmunity. In situations of autoimmunity, cannabidiol induces generation of Treg cells while other agents or therapies may be used to expand such cells in vitro and/or in vivo. In some embodiments the administration of cannabidiol is performed together with agents such as low dose interleukin-2 in order to treat inflammatory conditions such as arthritis or other conditions associated with reduction in Treg cells such as pregnancy failure, type 1 diabetes, or graft versus host disease. Type: Application Filed: September 2, 2020 Publication date: March 4, 2021 Applicant: Regen Biopharma, Inc. Inventors: Thomas Ichim, David Koos
Modulation of NR2F6 and methods and uses thereof Patent number: 9091696 Abstract: The application provides methods of modulating NR2F6 in a cell or animal in need thereof by administering an effective amount of a NR2F6 modulator. Type: Grant Filed: October 15, 2012 Date of Patent: July 28, 2015 Assignee: Regen Biopharma, Inc. Inventors: Christine Victoria Ichim, Richard Alexander Wells
CELLS, COMPOSITIONS, AND TREATMENT METHODS FOR STIMULATION OF HEMATOPOIESIS Publication number: 20150037303 Abstract: The invention discloses novel methods, compositions of matter, and kits for the treatment of disorders affecting the hematopoietic system. Patients are administered an autologous cellular mixture derived from adipose stromal vascular fraction, said cellular mixture comprising endothelial cells, endothelial progenitor cells, T regulatory cells, monocytes, and hematopoietic stem cells. In one embodiment, treatment is provided for patients suffering from inflammatory disorders including aplastic anemia. Type: Application Filed: August 1, 2013 Publication date: February 5, 2015 Applicant: Regen BioPharma, Inc Inventors: Thomas Ichim, David Koos
CANCER THERAPY BY EX VIVO ACTIVATED AUTOLOGOUS IMMUNE CELLS Publication number: 20140065096 Abstract: Disclosed are therapeutic methods for ex-vivo activation of immune cells from a cancer patient for the purpose of inducing tumor regression and/or suppressing metastasis and/or tumor recurrence. In one embodiment mononuclear cells of a patient are isolated from peripheral blood and activated by a combination of innate immune system activators together with means allowing for T cell activation. Type: Application Filed: August 2, 2013 Publication date: March 6, 2014 Applicant: Regen BioPharma, Inc. Inventors: Thomas Ichim, David Koos
ACCELERATION OF HEMATOPOIETIC RECONSTITUTION BY PLACENTAL ENDOTHELIAL AND ENDOTHELIAL PROGENITOR CELLS Publication number: 20130309210 Abstract: Compositions useful for treatment of patients needing hematopoietic stimulation. In one embodiment patients are administered a cellular mixture derived from allogeneic placenta, said cellular mixture comprising substantially of endothelial cells and endothelial progenitor cells. Type: Application Filed: May 20, 2013 Publication date: November 21, 2013 Applicant: Regen BioPharma, Inc Inventor: Thomas Ichim