It would appear to my untutored legal mind that intent to produce gV well beyond the amount necessary to fulfill the Trig>500 is direct evidence of intent to infringe. From what I recall we have evidence directly from HIKMA of intent to produce substantially more - that information was later taken off the internet .
Furthermore I posted previously ( see below ) direct evidence that the "general Understanding" was that HIKMA product would be used for reduction of CAD . Again direct evidence of intent to infringe