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DrBones

05/03/21 9:14 PM

#357877 RE: loanranger #357876

It only gives me access to abstract. Perhaps because I’m on my phone.
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farrell90

05/03/21 10:20 PM

#357882 RE: loanranger #357876

"...make the Brilacidin a most potent drug against SARS-CoV-2 than the known antiviral drugs."

Quite a quote and in a prestigious journal, no less.

Thanks for posting\,

Farrell

"Bio-computational designed Brilacidin is a synthetic non-peptide defensin mimic drug that destabilises the viral membrane by its amphipathic & hydrophobic nature, and its immunomodulatory property influence the expression of IL-1ß, IL-6, TNF-a cytokines, and cAMP& PDE4/PDE3 pathways which are associated with bronchodilator and anti-inflammatory effects of COVID-19 disease. The smaller size, more effective antimicrobial activity, bioavailability, low enzymatic degradation and toxicity, natural and low-cost production make the Brilacidin a most potent drug against SARS-CoV-2 than the known antiviral drugs."