Yes, I would agree Dr Missling and his management team have crafted a multi pronged approach whereby efficacy is able to be measured and confirmed along the way without unblinding the trial(s). Just take our drugs side effect of dizziness. Pretty hard to fake dizziness in a placebo arm. That coupled with RWE and RWD and its pretty safe to say care givers know who is and who isnt getting the drug because they are in constant communication with trial overseers especially during titration periods.
Also interesting is the Parkinson trials positive data with respect to the episodic memory portion further supporting the Alzheimer’s trials main endpoint of ADS Cog. Parkinsons secondary endpoints were mentikned again and from what I gather were pretty good, 3 rd party peer reviewed paper pending.
Over all again, in totality this doesnt have “failure” written on it. Dr Missling imo is not going through the motions here for a payche k and hairstyle perks. He does not continue to BS shareholders, institutional investors, regulators, current/future trial participants so yes, “it does sound like the drug really works.”