Many of us have been around here for a while, certainly, we have had our good days and our "not good" days but we have not struck out. There is one important point we (I) dance around when I talk w/myself about this.
Most of us understand that this is a medical game where you only get "ONE STRIKE". We are a serious, cautious bunch who after all this time will not settle for failure. That is what I sense w/Dr.M.. Perhaps he is unlike SAVA and BIIB upper magmt where "close enough" sometimes accepted. CNS diseases are hard ball, else this would have been over with a long time ago. "There is NO CRYING N BASEBALL."