"Tip of the Spear" work for me too. Tip of the Iceberg seems to fit Bio's DISEASE Z model a little better, no?
IMO, "Tip of the Spear is about focus and hitting the/a specified target."
"Tip of the Iceberg is about the study of a body of knowledge which continuously grows (example: CNS disease links)."
IMO, AVXL are doing both. This has all been about risk mitigation by/w/application of knowledge. Applied during/w exceptional science/execution/planning. It is not at all clear how else we got where we are. We must search for factual and theoretical science contradictions continuously as we power on this path. Overlooked contradictions are killers.
Continuous risk mitigation is exhausting work but failure is not an option.
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