Below is a report of some of his research describing the gain in function by genetic manipulation of Coronvirus and attempts to study vaccines against the lab created viruses.
"We report the in vitro reconstruction and biological character-ization, using reverse genetics and synthetic-genome design, of aninfectious clone of BtCoV HKU5 (icBtCoV HKU5) containing theectodomain from the SARS spike (S) protein (BtCoV HKU5-SE).We show that BtCoV HKU5-SE replicated efficiently and demon-strate that a small molecule inhibitor targeting 3CLpro effectivelyinhibited BtCoV HKU5-SE and MERS-CoV replication in cellculture. In addition, we report that BtCoV HKU5-SE replicated tohigh titers in both young and aged mice but did not cause life-threatening disease. Virus replication and disease were dependenton the presence of the mouse angiotensin-converting enzyme 2(ACE2) receptor, and immunohistochemistry staining demon-strated the presence of viral antigen in epithelial cells lining thesmall airways and alveoli."
The risky research was stopped temporarily in 2014:
There is speculation that cooperation between the North Carolina labs and the Wuhan labs led to the final development of Covid 19. The government denies these claims and others that Dr Fauci assisted the cooperation between the American and Chinese labs.They also state the Covid19 virus occurred naturally without genetic manipulation.
Linked below is a whistle blower lawsuit which claims the CDC, NIAID, and Dr Fauci illegally exchanged data with the Wuhan lab and others including Moderna.
Another report from 2016 of the North Carolina lab producing a virus similar to COVID 19 with the heads of the Wuhan Lab ( Zhengli-Li Shi} and Noth Carolina lab (Ralph Baric} as co authors.
" Using the SARS-CoV reverse genetics system2, we generated and characterized a chimeric virus expressing the spike of bat coronavirus SHC014 in a mouse-adapted SARS-CoV backbone. The results indicate that group 2b viruses encoding the SHC014 spike in a wild-type backbone can efficiently use multiple orthologs of the SARS receptor human angiotensin converting enzyme II (ACE2), replicate efficiently in primary human airway cells and achieve in vitro titers equivalent to epidemic strains of SARS-CoV. Additionally, in vivo experiments demonstrate replication of the chimeric virus in mouse lung with notable pathogenesis."