Replies to post #127 on Ardelyx Inc (ARDX)

[Whalatane]

HDG. thx ... I like CARA the most of the 3 CKD drugs we discussed. Will ask wife how many of her patients would need it...it may be more than I remember .
The itching disrupts sleep , causes lower quality of life as well as skin infections .
Need to chk the safety and AE notes but I remembered it as being safe .

Well after some DD ...NEJM

The incidence of adverse events in both trial groups was high, which is reflective of the susceptible population of patients who present with clinically significant coexisting conditions.
The most commonly reported serious adverse events and deaths appeared to be balanced across the trial groups.
Adverse events of diarrhea, dizziness, and vomiting were more frequent in patients receiving difelikefalin than in those receiving placebo.

Those on dialysis have it tough .
Suspect Cara's drug will only be used in those with severe Pruritus ( itching )
Kiwi