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B60611

03/02/21 6:01 PM

#301558 RE: TempePhil #301553

The only thing I can think of as to why he might not have PRed the trial enrollment completion (despite doing so for US Rett and PDD, and presumably ALZ) is because it probably occurred in late November and would've been greeted by groans from those waiting for US-Rett results. Still, he should've mentioned it in the several times he's talked since then (thanks for nothing, crappy analysts covering AVXL), but has chosen not to. I say late November because that's when clintrials updated with the new estimated study completion date of February 28, which fits timeline-wise with having just finished enrollment.

FWIW, we got US Rett results 6 months after the enrollment complete PR (so late May with my hypothetical timeline), and 3 months, 1 week after the LPLV PR.

nidan7500

03/02/21 8:25 PM

#301578 RE: TempePhil #301553

Maybe its time to stand back a little and see what the forest really looks like. IMO AVXL is leading the entire CNS bio parade. Look around. If he says what our protocol reveals he is giving away AVXL private strategy. We never did follow the FDA-Amyloid protocol while all the rest did. Now look, they are bailing out, screwed. We are learning, they are following.

We will shortly show how to run trials that go somewhere. Stand by.

We have serious flaws but I cannot see a better way. Our biggest issue is it just takes far too long to get results. But, just look around, no one is getting more trial- results.