Replies to post #326543 on Amarin Corp Plc (AMRN)

[Pharmacydude]

Ralphey
Conclusion: In conclusion, in hypertriglyceridemic patients with diabetes, metabolic syndrome, or obesity on statin treatment, EPA 1.8 g/d for East Asians such as Korean, Japanese, and Chinese and IPE 4 g/d for Western people could be a promising strategy to overcome residual risk in the statins era, if several aspects, including placebo issue, could be resolved. (Figure 3)

It’s 40 pages (with references) and a preprint. I haven’t read it yet but if you want a copy send me your email. Note: Funded by: Korean Society of CardioMetabolic Syndrome - thus the focus on the Asian population

Of interest to me was: The increased flux of free fatty acids associated with insulin resistance, obesity, metabolic syndrome, and diabetes caused endothelial dysfunction in part by activating innate immune inflammatory pathways upstream of NF-?B. Activation of NF-?B also increases synthesis and release of proinflammatory cytokines, which activate inflammatory cells and enhance
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their attachment to the vessel wall (Fig. 1).
Several mechanisms have been postulated.