Replies to post #35893 on Cel Sci Corporation (CVM)

[lightrock]

@george

Ok, from that same link

So you're right, not only is it a target, it is apparently one that can be introduced.

Counteracting the Subversion of Antigen Presentation
Several methods have been considered to maximize antigen presentation. For instance, tumor cells expressing MHC molecules are being used as vaccines. However, the more common approach is to transfer natural or artificial APCs that have been manipulated in vitro to display defined antigens (loaded under controlled conditions). Other in vivo approaches are being developed to limit the manipulations of host cells and to avoid cumbersome personalized immunotherapy. In this last section, we will address the needs to discover additional TAAs, improve cellular vaccines and define alternative methods to effectively stimulate CD4+ T cells.

[Biobonic]

Could be a target

Claims (46)

1. A method for modulating HLA Class II tumor cell surface expression in Squamous Cell Carcinoma to result in non-expression of HLA Class II on the tumor surface, which comprises administering to a patient in need thereof a serum-free and mitogen-free cytokine mixture comprised of specific ratios of cytokines selected from the group of IL-1ß, TNF-a, IFN-?, GM-CSF, Interleukin-2 (IL-2) where the specific ratios of IL-1ß, TNF-a, IFN-?, GM-CSF to IL-2 are:

Patent claim

On the other hand - I claim no medical or scientific background. Although was a straight A HS Biology student. We were studying dinosaurs back then - still living ones...