Replies to post #479 on Genocea Biosciences Inc (GNCAQ)

[NY1972]

Anti-PDL1 works in TDLN not TME.

In a mouse model of acute viral hepatitis, the absence of PD-1 is associated not only with more rapid virus clearance but also with more severe hepatitis (Iwai et al., 2003). These results imply that the stimulation of the PD-1/PD-L1 axis during the acute phase of virus infection helps to adjust the strength and quality of the cytotoxic CD8+ T cell attack so that the good (virus elimination) and the bad (tissue damage) is balanced, preventing excessive tissue damage.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584848/