Replies to post #292191 on Anavex Life Sciences Corp (AVXL)

[ExtremelyBullishZig]

I am long Anavex and post realistic comments. The company has no business putting to many irons in the fire. I can be happy with my investment and disagree with what they are doing with investment. Or we could all act like we are on cocaine and that it is pure bliss all the time. That is called ignorance...

Anavex is a good bet, not proving yet to be a good company.

[tradeherpete]

Hi Elsa Sara,

If you haven’t read it, I did a transcript of Dr. Hagerman’s presentation. In that you can see where she begins; “I was blinded during the control trial.”

Then later says: “I have been involved now in the follow up where they go on the active medication so I can see actually the results now in individuals that I know are on medication. “

I believe Randi may have been seeing the placebo group when talking about “others that didn’t.”

That’s my assumption.

I’ve included the whole thing for you here.

Thanks for posting. Hopefully the light shines on Anavex soon as it’s Science is brightening up the prospects for millions of people.

Pete

Anavex is talking about approval for Rett after the phase 2 trial in Us, why?...it sounds pretty optimistic!
Dr Hagerman on the webinar´s Rett said about Us Rett trial " I saw a number of individuals who did very well on this medication and others who didn't.."
Dr Missling, last CC: " We expect the hight dose to even stronger effect size"
I think that the answer is pretty obvious...what are they seeing in the Avatar study??? ummmm...big response.. or maybe huge response in a few individuals ?

Dec. 16, 2020

Presentation at the ladenburg Thalman Health Care Conference.

Hi I’m Dr. Randi Hagerman,

I’m a Clinician, I’m a developmental and behavioral Pediatrician and I have a great interest in the use of targeted treatments for a variety of neuro-developmental disorders. And again by targeted treatments, I mean medications that can modify the neurobiological changes that are made in the brain and individuals with neuro-developmental disorders. I participated in the Adult Rett Syndrome Study using Anavex2-73.

The results are being released now and these are very exciting results.

I was blinded during the control trial where individuals were randomized either to active drug, about 5mg a day vs. placebos so I didn’t know who was on what.

I saw a number of individuals who did very well on this medication and others who didn’t but also I have been involved now in the follow up where they go on the active medication so I can see actually the results now in individuals that I know are on medication.

I saw a variety of improvements and again as you heard in the last talk from Jeff, these individuals are very severely impaired.

They can’t talk or talk very little, often they’re in wheel chairs. They can’t use their hands well . They often times can have agitation, other types of problems like constipation and what we saw is that individuals were calmer, less agitated, they seemed to be happier. They were able to concentrate better. They made better eye contact and they seemed to understand questions or directions given to them and were able to follow through in many cases on some of the commands that their parents made.

There was less anxiety, better understanding and in general the parents felt they were calmer and less agitated and often we saw improvements in the gastrointestinal problems.

One patient that stands out that I just recently saw, was able to swallow her food better. She didn’t have any problems choking now that she’s on the active medication.

She was able then to eat better, happier. She had less bloating, less constipation and having better function GI wise I think can lead to less agitation.

The families were able to mark on the main outcome measures that were improved. The Rett Syndrome Behavior Questionnaire that the parents answered and also the Clinical Global Improvements Scale. The CGII that the Clinicians do. There were significant improvements with the Anavex2-73.

So this is very exciting.. So far the patients want to continue on the Open Label Extension on this medication.

This is a relatively unique medication that can actually improve the calcium dis-regulation, the mitochondrial function, the oxidative stress and the neural connections. These problems can be seen in variety of other neural developmental disorders and also neurodegenerative disorders.

They’ve carried out studies in Alzheimer’s and in Parkinson’s Disease looking at cognition in Parkinson’s disease. It improved cognition in both Alzheimer’s and Parkinson’s disease.

I do a lot of research also in Fragile X syndrome and this medication can improve the Fragile X symptoms in the mouse model of Fragile X so I’m very excited about this medication causing improvements not just in Rett Syndrome but in other neuro-developmental disorders and neurodegenerative disorders.

This medication can be a boon. I think in general for aging and certainly for aging syndromes like Parkinson’s Disease and Alzheimer’s and I can’t wait to start it on other neuro-developmental disorders like Fragile X Syndrome.

I am very excited about this medication and also as I age I would definitely like to take Anavex myself.

I’m excited that this is a break through medication and for not just Rett Syndrome but other disorders of aging and also neuro-degeneration.

We are open to answer questions that you may have.

This is an exciting new treatment.