Replies to post #342378 on NorthWest Biotherapeutics Inc (NWBO)

[Dr Bala]

Not true again.

[learningcurve2020]

LOL. That’s the first time I think anyone here ever referenced the company’s website!

[flipper44]

You know damn well that NWBO/Mayo Clinic has designed and is awaiting to start a Direct trial. Funding is an issue until current DCVax-l resolved. https://clinicaltrials.gov/ct2/show/NCT03638765?term=Autologous+dendritic&cond=Brain&draw=3&rank=3

The study will use an Ommaya reservoir that drains into brain metastases to deliver activated, autolous dendritic cells to the tumor lesion, for patients who are 18 - 75 years old who have brain metastases from either lung cancer or breast cancer. The primary objective of the study is to evaluate the safety and feasibility of administering DCVax-Direct to patients with metastatic tumors in the brain. The secondary objectives are to determine tumor response, the rate of intracranial recurrence (IR), the rate of neurologic deaths, decline in neuro-cognitive functioning and overall survival. Approximately 10 patients with injectable metastatic brain tumors will be enrolled initially in a dose escalation scheme, with the expectation to enroll a total of 24 patients.

[CogDiss 1188X]

The PhII stage never happened (imo) as it would have exposed Direct as a totally ineffective therapy.

Kind of disappointing, Mr Doe. You know phase 1 doesn’t prove anything, especially that a treatment doesn’t work. If proof of efficacy was required in phase 1, no drugs I’m aware of would ever proceed to phase 2.

So why would you say it was totally ineffective? How could you possibly know, or even opine that?