Replies to post #22930 on Humanigen Inc (fka HGENQ)

[ohm20]

IL-4 and IL-13 prevent the downregulation of CCR5 by GM-CSF. So in a high inflammatory state GM-CSF does not affect CCR5. Conversely CCR5 blockade and downregulation of IL-4 and IL-13 does downregulate GM-CSF. Nice little interruption of a feedback loop by leronlimab.

[ohm20]

If you want an example of direct action CCR5 blockade downregulates IFNy, lowering IFNy downregulates IL33. IL33 is a driver of GM-CSF expression.