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ohm20

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ohm20

Re: tscott4 post# 22930

Tuesday, 12/15/2020 10:29:38 PM

Tuesday, December 15, 2020 10:29:38 PM

Post# of 43125
IL-4 and IL-13 prevent the downregulation of CCR5 by GM-CSF. So in a high inflammatory state GM-CSF does not affect CCR5. Conversely CCR5 blockade and downregulation of IL-4 and IL-13 does downregulate GM-CSF. Nice little interruption of a feedback loop by leronlimab.
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