God forbid...but if I had developed pancreatic cancer
Then first would come the 1st line treatments. Where there are two primary ones. Would request an add on treatment that quadruples the chance of successful surgical removal of the primary tumor. If surgery is successful then one has 2+ yrs. And in that time one could try an immunotherapy to prolong remission. Also, attempt the "personalized" medicine approach. Test for such things as BRCA1/BRCA2 mutations which could allow the use of PARP inhibitors- as part of maintenance therapy(?).
Then would come 2nd line therapy. Nanoliposomal irinotecan either alone or in combo with other drugs is gaining for 2nd line usage. Recently approved in the OFF (Oxaliplatin/Folinic Acid/5-FU) protocol.
Likewise in 2nd line "personalized" medicine comes into play. NTRK fusions, if present can be treated with larotrectinib or entrectinib.
If now a 2nd line patient, and wanting to go to the bleeding edge, one could try getting into a CT involving immunotherapy with an IL-15 agonist, and an anti-PD-L1 drug in combo with chemo.
So where does the desperation of "and had no other treatment solutions available" come from? And we're not through...
One's oncologist could explore what it would take to get one into a BL-8040 CT. And if that isn't available, and one is becoming more fragile or unable to tolerate chemo, there is GRASPA. Extremely low toxicity. None of the usual chemo effects.
What one wouldn't do is read a Kenny PR pump, and then "be cursing the fda for not letting this technology move forward". Because there's no sound science that says the Kenny Wonder Treatment will do anything. Instead if one was seeking as a last ditch effort some palliative relief using an alkylating drug, then one would inquire about Glufosfamide. If approved by then for 2nd line cancer, then inquire from the oncologist whether to go off label, combining it with immunotherapies. Where any subsequent cursing involves insurance companies for not wanting to cover the treatment.
In summary... the Kenny PR pumps can imply there is an "un-met" need, and that there are no 2nd line treatments available, all that he wants to. But it isn't reality. There's a myriad of treatments, with more on the way. Treatments far superior to the 20 yr old antiquated Kenny Wonder Treatment.
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