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Review
Relevance of endoplasmic reticulum and mitochondria interactions in age-associated diseases
Author links open overlay panelAuroraGil-HernándezAlejandroSilva-Palacios
https://doi.org/10.1016/j.arr.2020.101193Get rights and content
Highlights
• Intracellular communication can be affected by aging and cellular senescence.
•The structure, bioenergetics, and dynamics of mitochondria change in old animals and humans.
•Both proteostasis and endoplasmic reticulum becomes dysfunctional with age.
•MAM could be key points in the modulation of lifespan and longevity in aging models.
Abstract
Although the elixir of youth remains in the darkness, medical and scientific advances have succeeded in increasing human longevity; however, the predisposition to disease and its high economic cost are raising. Different strategies (e.g., antioxidants) and signaling pathways (e.g., Nrf2) have been identified to help regulate disease progression, nevertheless, there are still missing links that we need to understand. Contact sites called mitochondria-associated membranes (MAM) allow bi-directional communication between organelles as part of the essential functions in the cell to maintain its homeostasis. Different groups have deeply studied the role of MAM in aging; however, it’s necessary to analyze their involvement in the progression of age-related diseases. In this review, we highlight the role of contact sites in these conditions, as well as the morphological and functional changes of mitochondria and ER in aging. We emphasize the intimate relationship between both organelles as a reflection of the biological processes that take place in the cell to try to regulate the deterioration characteristic of the aging process; proposing MAM as a potential target to help limit the disease progression with age.
Graphical abstract
