It's a subjective but important concept. You can have statistically significant results of a drug that shows no clinically meaningful impact. Generally speaking, clinically meaningful means it improves the patient's quality of life.
If you're overweight, losing weight is good. If a drug is shown to help adults, stat sig, lose one pound on average, that is not considered clinically meaningful. Stat sig is in no way scalar to the null hypothesis of a test of "lose weight'.
We"be been told that folks "lost weight" with stat sig confidence, but not how much. It is likely clinically meaningful given the company call and other indications, but these are not reliable unfortunately. We'll find out soon. Should be good.
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