Replies to post #300537 on Amarin Corp Plc (AMRN)

[mivan]

Thank you HK for your detailed analysis of Hayashi, I learn so much from your explanations.

I never understood a point: how it can be concluded that looking at the standard deviation there must have been at least a patient with trig > 533?
Would a mathematician reach that conclusion? I believe no.

He would reach the conclusion that there could have been a patient above 533 with the same amount of probabilities that there was a patient below 67

Maybe it can be said that there is a bigger chance that a patient was >533 than a patient <67, but not that there MUST have been a patient abot 533

Please correct me, I long forgot my math lessons and I may be mistaken

[iwishiknew]

HK, Please return to your Hayashi paper. I think you meant to use scatter plots on figure 2 (triglycerides x-axis) rather than figure 1 (chol x-axis). X-axis ends at 400-450 and N is <total population for the y=axis testing. Also, not sure how you got the std curve mean at 300 w std 133. Table 1 TG at baseline 300 +/- 233.
Also, from the paper p26 "LDL cholesterol (LDL-C) concentration was calculated by the Friedewald equation" - so, didn't calculate it for subjects w TG >400 (I guess).