I know people have been pointing to that article as a reason for optimism but it looks like a recent weak SA article with the same deficiencies. I read these articles discounting any general S1R effect and look for something specific to 2-73. This is because: 1. S1R agonists have been used in PDD without sufficient success to lead to an indication in the disease 2. AVXL has not shown any credible reason 2-73 should succeed where other S1Rs have failed.
Reading it without general S1R effects what's left?