Replies to post #112015 on Cytodyn Inc (CYDY)

[KCRoyal2004]

I feel that is a valid concern, but obviously don't know it's potential impact on statistical significance.

[IndexGuy]

Has the standard of care really improved, or have we just reached a point in this pandemic where the vast majority of the patients are in the low-risk age bracket? That's what's happening out there.

College age kids are getting it by the tens of thousands, and they are simply not at high risk for mortality like the over 70 crowd.

[Borel Fields]

Yep, reduced overall mortality decreases statistical power. Those power calcs were on this board long ago - have to revisit.

The trial has been modified twice to offset the trend. First, the age limit (prev <65) was removed. Then they changed language regarding intubation at admission.

Every effort to keep this the "trial of the sickest."

[The oNiOnHEAd]

That's an interesting consideration; Big Pharma/FDA trying to delay, delay, delay, as beating the standard of care becomes more and more difficult. But I see no way to know if that's the case.