well good question.
To uplist to the Nasdaq a company must have a minimum SP of $ 4, a minimum of 1,250,000 publicly traded shares.
For NWBO to get to a MC of 4 billion I do think they will have to make some sort of a deal with a large investor and or have a serious amount in royalty payment from a big pharma.
An R/S is really a desperate attempt in most cases to keep the company afloat. It would have made more sense for NWBO to have done so a year ago. So no I dont think that NWBO will reverse split after positive topline data. I think NWBO will partner MC will get to over 4 billion and then list up (as part of the terms with the investor). Most companies have done it in this manner. However, this is NWBO, one never knows for sure..