Replies to post #283510 on Amarin Corp Plc (AMRN)

[rosemountbomber]

Thanks for the article, but it is not Vascepa. As a matter of fact, it shows that you have to strike when the iron is hot, because you never know when competition will arrive.

[Jasbg]

johnking@ How often for the last 20 years did you read about a 'Cure for Cancer' - or a long line of other very bad diseases.
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If something sounds 'too good to be true' - it usually is' - and maybe even most in Bio World.

And playing with Gens'- maybe their ears suddenly start to grow 'a couple of years later' :)

Jasbg

PS: An article like that is 'bread for day traders' and "family" of staffs.

[jessellivermore]

John King...

Quote ACC CVOT results...Evolacumab (PCSK9 inhibitor)

Interpretation:

Among patients with elevated cardiovascular risk on statin therapy, evolocumab versus placebo was effective at reducing adverse cardiovascular events. Evolocumab was associated with marked reductions in LDL-C levels. Serious adverse events were similar between treatment groups. Efficacy for evolocumab was similar among those with very low baseline LDL-C levels. There was a greater absolute reduction in major adverse events for evolocumab versus placebo among those with the highest baseline inflammatory risk and genetically determined high-risk status. PCSK9 inhibition represents a novel approach to lower LDL-C levels and improves cardiovascular outcomes. However, for the duration of follow-up, there was no benefit on cardiovascular or all-cause mortality, and cost remains an issue.

The treatment of heart disease is like "affirmation" you repeat a 1000 times "I believe I can do it"..Then on 1001 you say "no". The treatment of atherosclerosis has been under the guidance of cardiologists and lipidolgist for the past century and they have focused lipid levels and it is becoming more and more obvious they should be focusing on Systemic Inflammation (SI)..Blood markers such as trigs, sugar, and likely LDL-C reflect the SI and the R-I trial even though the cardiolgist (including Bhatt) have refused to consider the Inflammatory levels related to changes in the EPA/AA ratios (something we have not heard about) R-I's legacy will be its confirmation that elevated SI is the root cause of cardiovascular disease and is the "puppet master" and the blood markers are only the puppets..

Right now I would much rather be holding the deed to Vascepa rather than any drug that merely lowers blood lipids unless it is doing it by lowering SI...

":>) JL

[sts66]

That's playing god - changing someone's genes is beyond risky, never know what the long term effects are going to be - there's a good reason why creating "designer children" is banned in most of the world.

[Hey Jakey]

Yeah, I freaked a bit when I first saw that too, but this is many years (a decade +?) away if it ever happens. Let’s say it works, there will be huge segments of the population who either cannot afford and/or do not want gene therapy. It’s hard enough to get folks vaccinated or to stop eating a bacon cheeseburger/day. Can you imagine the batshit crazy public response to mass marketing gene editing for something like heart disease? We’re not talking sickle cell here, which at least tries to convince you to try gene therapy due to the incredible pain it unleashes. And what’ll they’ll charge for that? And presumably with none of the pleiotropic effects of pure EPA. Anyway, no longer freaking out. They got a LONG way to go.