Replies to post #275589 on Amarin Corp Plc (AMRN)

[ggwpq]

JL, thanks for mentioning Friedewald Equation again:

LDL = TC(total cholesterol)- HDL-C(high density lipoprotein cholesterol) -Trigs/5

For SHTG (TG>500), a POSA should expect TG reduction to be above 30% for using DHA/EPA
For HTG, a POSA should know the TG reduction is about 10-20% for using DHA/EPA

Therefore, the greater the %TG reduction, i.e. SHTG population, a POSA should expect a greater rise in LDL-C. So a POSA looking at Mori and saw EPA raised LDL-C for even a marginally above average TG population, he should stay as far away from EPA as possible for SHTG population. That's why experts said increased LDL-C was inevitable for SHTG lowering therapy and that's why there was such a long unmet need after Mori until the discovery of Vascepa. Only hindsight could force Mori to be a valid prior art.