Replies to post #283464 on NorthWest Biotherapeutics Inc (NWBO)

[longfellow95]

"Italy Finally Starts Mass Treatment with Hydroxychloroquine"

This article was some 6 weeks ago.

Doctors in Italy have finally began widely prescribing hydroxychloroquine in certain combinations in Rome and the wider region of Lazio with a population of around six million.

According to Corriere della Sera, a well known Italian daily newspaper, Dr. Pier Luigi Bartoletti, Deputy National Secretary of the Italian Federation of General Practitioners, explains that every single person with Covid-19 that has early signs, like a cough or a fever for example, is now being treated with the anti-malaria drug.

The drug “is already giving good results,” Bartoletti says while Malaysia reveals they have been using it since the very beginning. Bartoletti further adds that the drug:

“Must be used with all the necessary precautions, it must be evaluated patient by patient. It can have side effects. But those that take it are responding really well.

We have just understood that the virus has an evolution in two phases and that it is during the second phase, after a few days (about a week), that the situation can suddenly, in 24 or 48 hours, worsen and leads to respiratory failure requiring intensive care.

The results that we are starting to accumulate suggest that hydroxychloroquine administered early, gives the possibility of avoiding this evolution in a majority of patients and is also helping us to prevent hospitals from filling up.”

Incredible. What is more incredible are the statements of Professor Christian Perronne, Head of the Infectious Diseases Department at the Garches University Hospital, made in an interview with a French weekly magazine.

Referring to the European Discovery trial in which UK is taking part with only 800 patients, Perronne says:

“I refused to participate because this study provides for a group of severely ill patients who will only be treated symptomatically and will serve as control witnesses against four other groups who will receive antivirals. It is not ethically acceptable to me.

We could perfectly well, in the situation we are in, evaluate these treatments by applying a different protocol. In addition, the hydroxychloroquine group (which was added to this study at the last minute), should be replaced by a hydroxychloroquine group plus azithromycin, the current reference treatment according to the most recent data.

Finally, the protocol model chosen will not provide results for several weeks. Meanwhile, the epidemic is galloping. We are in a hurry, we are at war, we need quick assessments.”

America is to start yet another study which is to take one month even while one thousand people or more are dying worldwide today. In Italy however doctors are finally not waiting anymore with Perronne saying:

“Even though the overwhelming evidence from large randomized studies is still lacking, I am in favor of a broad prescription for the following reasons:

1. We have a large body of evidence showing that in vitro hydroxychloroquine blocks the virus. We also have several clinical results indicating that this product is beneficial if administered early and we have no mention that it harms or is dangerous in this infection (only one study, poorly detailed, Chinese, on 30 patients with control group, did not observe any benefits but also no harmful effects). What is the risk of administering chloroquine straight away: nothing!

2. This drug is very inexpensive 3. It is well tolerated in long-term treatment. Personally, I have successfully used it clinically in the chronic form of Lyme disease for 30 years at a dose of 200 mg or even 400 mg/day.

I and hundreds of other doctors are able to judge its excellent tolerance in humans. The main contraindications are severe retinal and unbalanced heart disease.

Cardiovascular events remain exceptional if care is taken: to proscribe self-medication – to check with the elderly taking a lot of drugs that there are no drug interactions (with long-term diuretics in particular) and that the rate of blood potassium is within the norm.

Apart from these precautions, the undesirable effects are minor. They are even more so as the treatment is short, which is the case against Covid-19.

It would therefore be wise to produce hydroxychloroquine in very large quantities without further delay, to make it easily accessible to infected people…

https://www.trustnodes.com/2020/03/29/italy-finally-starts-mass-treatment-with-hydroxychloroquine


Italy's death have been in steady decline, since this point in time.
And since that same point in time, the UK's deaths have surpassed Italy.

[biosectinvestor]

You guys have a need to spread anecdotal nonsense, and ignore the main studies.

I don’t search only for studies that were not good, those are the only ones completed, and one was detrimental enough for patients they had to end it early. It made patients worse.

Then there are the conclusions... see, this story from this strange source says that ALL of Italy is prescribing it and see how deaths have gone down since that date. Causality is not proven that way.

New York prescribed it to everyone because of the politicization of the issue, not because it was the best treatment. Because it was available and all the Federal sources were politicized and you must really prescribe it if Agencies are making it available and suggesting you really should, while still warning there is no evidence yet...

Nonetheless, during that time NY’s rate of infections and deaths skyrocketed. And for those who say the US doctors are prescribing it across the board, great. Then why is the US Coronavirus central for the planet? Why do we have more infections and deaths than anywhere else even though we’re not testing in much of the country?

It’s cause “liberals” or “media bias” or some such nonsense.

You don’t prove causality either way, either by noting infections and deaths went up and anecdotally doctors here are prescribing it, not is the inverse a true statement, that once we started prescribing it, see how infections and deaths went down. That is pure rhetorical, political nonsense and has nothing to do with anything. It’s seeing what you want to see.

But there are trials. Right now, the best trials so far have shown that it is probably not helpful, could be harmful, and we are waiting on other evidence to show if there could be situations where it might help. But Trump is not a doctor. I’m not going to conclude it will cure or prevent Coronavirus because he was politically praying for a miracle cure while simultaneously claiming Coronavirus was a hoax, or that we only had 15 cases and it would disappear with warm weather in April. He has been consistently wrong, he does not care about evidence and he lies about everything, even his own physicals.

That people have so much of their face invested in Trump being correct on this one topic, I think says more about the strange state of the US at this time, than it does about Coronavirus or science or media. It’s a strange brand of kool-aid.

As I said from the beginning, if your doctor won’t give it to you and your having panic attacks cause you can’t have it, switch doctors. That’s on you though, if it doesn’t help or makes you ill. But by all means, get it. That you have a need to tell other people they are being “denied” or should request it against their doctors advice, that’s another thing. It’s cultish recruitment, it’s not good advice to disregard your doctor’s advice. Is it worth looking into? Maybe they can ask? Sure, but dated articles from March... that’s not helpful.