Replies to post #250444 on Anavex Life Sciences Corp (AVXL)

[falconer66a]

But What If Given Early?

Or at least reduces the mouse model symptoms. Would be interesting.[administration of blarcamesine in transgenic mice with developed, fully-symptomatic Alzheimer’s.]

Yes, the accumulation of elevated levels of mitochondrial calcium ions were clearly associated with, probably caused or contributed to Alzheimer’s symptoms.

What might happen, then, if blarcamesine (Anavex 2-73) were administered to the Alzheimer’s mice before any symptoms developed; before the accumulated calcium might have precipitated the amyloid deposits?

In this case, would blarcamesine be successfully prophylactic; a prevention of the onset of Alzheimer’s symptoms?

Wouldn’t be difficult to test this. Results would provide greater clarity of a specific mechanism of action (MOA) of blarcamesine.