"If that is too difficult to answer, as you would have to get into their minds, perhaps an easier question is how many physicians, a decade ago, recommended that their patients take EPA? Is the answer similar to the P value of REDUCE-IT's primary endpoint? "
I don’t think anyone would have come to that conclusion - zero. And the real key is that no company was willing to invest several hundred million to test the theory because it wasn’t clear enough. That’s part of why the secondary considerations are important since they took the risk on behalf of the public good.