Replies to post #261062 on Amarin Corp Plc (AMRN)

[jessellivermore]

James..

I hope my post can be understood...The judge has a simplistic view of how trigs are related to clinical conditions..She thinks High trigs are like a poison..So she thinks obviously lowering the trigs will get rid of the poison and since Mori showed both EPA and DHA lowered trigs then they should "obviously" be used to treat Pancreatitis..EPA would be preferred because it has the added benefit of not raising LDL...Actually the n-3s do not work by that simplistic MOA...DHA actually lowers trigs on a mg basis more than EPA does..But no one has suggested DHA as a stand alone for Acute Pancreatitis..

and more to the point EPA and not DHA is more effective at lowering CVD event risk because it and not DHA can interact with the Eicosanoid receptors which are on all cells save Red Blood Cells...and the Eicosanoid receptors are the main determinants of Systemic inflammation..Not the trig levels..

":>) JL