Thanks, HadToHaveit, I would like to address you thought as to the not to "easy" use of the Cytosorb filter. Just in the city I am in less than 1 million people, there are about 30 Hemodalysis clinics. Each clinic has back-up dalysis machines, some clinics have older machines that still work, but are currently not in use. Each clinic has at least 1 RN on duty during clinic hours, along with LVN's and Hemodalysis Techs. These people are trained in blood perfusion devices which the filter is a part of. The priming of the filter and getting the blood flow rate is what they do. I believe with a little bit of extraordinary effort, a lot of the critical needs of the filters infrastructure could be met considering the percentage of those needing our filter is quite small relative to the entire picture. Not that it would be easy, but doable. Stay safe!