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04/01/20 6:18 PM

#274654 RE: IkeEsq #274585

Good to hear Ike. I've got 5 questions so far.

Please respond with your questions to my post up in the Plus One Section.

People, get your questions in!



1. (Jack2479)
The relationship between Advent Bio - a private company owned by Mrs Powers and Northwest Bio - a public company with Mrs Powers as the CEO sits uncomfortably with many shareholders. Especially as Northwest funds were used to acquire the site and essentially build the manufacturing facilities. The lease is in the name of Northwest Bio. Notwithstanding the need to keep commercial contracts secret can you explain to shareholders why it serves our best interests to have Advent Bio independently market themselves from their website as follows -

“Advent Bioservices began activity as a cell therapy contract development & manufacturing organisation (CDMO) in 2016. We are currently currently managing the development of a state-of-the-art facility for multiproduct GMP production outside Sawston in Cambridgeshire, which will allow scale up of current commercial production and initiate the provision of contract manufacturing services to meet the growing demand for such services in the UK.

The Sawston facility is located just 7 miles outside Cambridge city centre with excellent transport links to Central London, London Stansted airport and it is 4 miles from the M11 motorway, linking to the Midlands by the new A14 extension.

The facility consists of GMP lab space and process development and additional areas for future expansion. Initial construction work has focused on the building of 2 separate GMP suites with grade B/C classified areas, in house QC testing and office space as well as a multipurpose cryogenic storage unit.

We will operate the facility under a comprehensive IT infrastructure including eQMS and an eBMR, with a LIMS with secure storage for client documents and paperless systems. Clients Operations within these suites will benefit from already validated cleanrooms, in-house environmental monitoring system as well as training, ancillary services and technical support inclusive of process development and validation. The cryogenic facilities are available to external clients as off-site storage and offer disaster recovery services as per UK regulatory (HTA) requirements.”


There is what appears to shareholders a potentially obvious conflict of interest between our CEO and a private company she owns and it’s relationship with Northwest Bio and the facilities they own. My question is -

What good reason is there why Advent Bio is not a full 100% subsidiary of Northwest Bio? Why is it in our best interests to have our CEO independently own it ?

2. (791Branko)
Is there a limit to the number of patients that can treated on their UK Specials Program?

3. (IkeEsq)
What if any impact is Covid-19 having on this process or NWBO in general?

4. (Vator)
still wonder about the colorectal Mainz trial. Did work take place? If not is it planned in the future? The hospital was supposed to fund it. What happened. That is a question for the ASM.

5. (ae austerer)
Now, please tell me with a "ramp "in production in process , how many patients per month will be paying $200,000 when the "ramp" is complete?

reg2015

04/01/20 6:33 PM

#274661 RE: IkeEsq #274585

Simple question: On such and such date, (the latest available from our reporting agents in the blinded/blended phase III DCVAX trial) how many are still living? Please tell us date and #. Thank you IkeEsq and I hope this is relevant. If not ignore it. Peace and Safety Reg 2015