Agreed... if personalized medicine is the way forward in treating cancer, then understanding what works with what subgroups seems essential. When the DCVax trial first began, defining the various subgroups, including mesenchymal, hadn't even been established. And given that the mesenchymal subgroup is one of the larger subgroups, and other subgroups can actually develop into that subgroup, I think it's entirely reasonable to think that the FDA would be open to considering this when evaluating for approval, should the need arise to use this type of data.