Replies to post #143182 on NanoViricides Inc. (NNVC)

[Nanotoday]

...just like what Diwan/Theracour/NNVC is doing

That's funny.

What exactly do you think they're doing, this very minute, in Diwan's Shelton facility?

You think it's anything close to what Sorrento is doing in their facility?

(looks like the checks are still coming in, virus or no virus)

[KMBJN]

What NNVC says it is doing:

The Company determined, based on molecular modeling screening that it had in its chemicals library ligands that could bind to SARS-CoV S1 spike protein at the same position where the S1 binds to the human receptor ACE2. It is a reasonable expectation that these relatively broad-spectrum ligands would also be able to bind the S1 spike protein of the NCP coronavirus in the same fashion. The Company intends to generate nanoviricides based on these ligands and test them in our own BSL2 virology lab facility against known available human pathogen coronaviruses, including those that use ACE2 as the cellular receptor.

compared to Sorrento:

STI-4398 is a proprietary ACE2 (angiotensin-converting enzyme 2)-Fc fusion protein (COVIDTRAP). The STI-4398 protein binds to the S1 domain of the spike protein, which is expected to block the spike protein of the SARS-CoV-2 virus to bind the ACE2 receptors present on the target respiratory epithelial cells. Without the ability to penetrate target cells, the SARS-CoV-2 virus cannot replicate and spread itself.

In vitro cell studies for SARS-CoVID-2 virus infection and neutralization are expected to be conducted in the next few weeks in collaboration with world-leading coronavirus experts.

Both are making virus traps / killers, using ACE2 molecular mimics.

[KMBJN]

Recently published was another nanomolecular decoy concept, using phage viruses to envelope influenza. What a breakthrough this would be. NNVC uses the same concept for their FluCide. NNVC uses a polymeric amphiphilic nanomicelle, whereas this other group uses an engineered phage capsid. I believe NNVC's nanomicelle is around 20 nm in diameter, and this QB phage capsid is icosahedral shape with 25 nm diameter. Coat protein on phage capsid forms triangular geometry that matches the physical structure of HA trimer. Will see if these folks in Germany have any better luck getting funding and getting into trials:

https://www.nature.com/articles/s41565-020-0660-2

Here, we propose bacteriophage capsids as rigid scaffolds that are functionalized by a structurally defined presentation of Sia ligands to match the binding sites of the trimeric HA.

Sounds familiar.