On page 18: OPTIMA Study: Blinded PFS Data Consolidated for Both Arms my consern is HEAT subgroup gets the P value down to 0.02 from OS wide separation tail of the KM curve, and OPTIMA PFS crossed down below subgroup PFS at 42 month time mark, and Subgroup flat at 27% on 38 month time mark vs OPTIMA falt at 18% on 46 month time mark, raise concern OPTIMA OS tail may not be as good as the subgroup that affects P value at second look, IMO.