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GD

Re: stockweiser post# 16526

Tuesday, 02/11/2020 2:20:53 PM

Tuesday, February 11, 2020 2:20:53 PM

Post# of 16750
Here is the CLSN new presentation from Jan 28, 2020:

http://investor.celsion.com/static-files/70e45734-e80b-41dd-b6af-e19f435f46c0

On page 18: OPTIMA Study: Blinded PFS Data Consolidated for Both Arms
my consern is HEAT subgroup gets the P value down to 0.02 from OS
wide separation tail of the KM curve, and OPTIMA PFS crossed down
below subgroup PFS at 42 month time mark, and Subgroup flat at 27%
on 38 month time mark vs OPTIMA falt at 18% on 46 month time mark,
raise concern OPTIMA OS tail may not be as good as the subgroup that
affects P value at second look, IMO.