Replies to post #14447 on Therapeutic Solutions International Inc (TSOI)

[centsability4me]

It is a long read , but worth it .

After reading it, there were a few things that I found interesting :

In contact dermatitis (CD) PTER prevents cell apoptosis and inhibits IL-1ß-related NLRP3 inflammasome activation.

Hexavalent chromium (Cr(VI)) is widely used in many industries but can induce contact dermatitis especially in cement industries.
https://www.ncbi.nlm.nih.gov/pubmed/30486377

Possible mechanisms involved were investigated to see whether chromium-induced CD could be effectively inhibited by treating with PTER.


For those that want to go a little bit farther in the DD , I've added some basic background info on Hexavalent Chromium:

Hexavalent Chromium Compounds
https://www.cancer.gov/about-cancer/causes-prevention/risk/substances/chromium

What is chromium and what are hexavalent chromium compounds?

Chromium is an odorless and tasteless metallic element that is found in the earth’s crust. It is also found in air, water, soil, and food.

Hexavalent chromium compounds are a group of chemicals that have useful properties, such as corrosion resistance, durability, and hardness. These compounds have been used widely as corrosion inhibitors and in the manufacture of pigments, metal finishing and chrome plating, stainless steel production, leather tanning, and wood preservatives. They have also been used in textile-dyeing processes, printing inks, drilling muds, fireworks, water treatment, and chemical synthesis.

How are people exposed to hexavalent chromium compounds?

Occupational exposure to hexavalent chromium can occur from inhalation of dusts, mists, or fumes containing hexavalent chromium, or from eye or skin contact. Industries with the largest number of workers exposed to high concentrations of airborne hexavalent chromium compounds include electroplating, welding, and chromate painting.

Which cancers are associated with exposure to hexavalent chromium compounds?

Occupational exposure to these compounds is associated with increased risks of lung cancer and cancer of the paranasal sinuses and nasal cavity.


Have a great weekend biotech18 , and all you traders that have the patience to wade through the technical jargon . The papers of interest can take time to comprehend , but are well worth the time it takes to better understand current TSOI R&D .
-Cents