Replies to post #54833 on Cytodyn Inc (CYDY)

[misiu143]

Theoretically it is possible , when reservoir cells will die ,and be replaced , and within 7-9 years they all will ,

Now , in between if patients will for whatever reason not be doing well , , new reservoir may form , so in practice it is less sure.


Just IMO. Will love Ohm , Blane and others opinion here..

[ohm20]

One of my early posts elsewhere after buying Cytodyn stock. I've always wanted to see the data for virus levels across the entire 5 year span to see if the below 1 virus levels occurred near the end of that time span.


[/quote]CD4+ memory T-cells (where hidden HIV reservoirs hide) differentiate themselves after the naive CD4+ T-cells are already produced and in response to an event. As long as there are any CD4+ cells with active CCR5 receptors than CCR5 specific HIV can reproduce when the hidden reservoirs of HIV activate.

With CD32 T-cells there are no CCR5 receptors. With bone marrow transplants chemo will destroy the existing blood producing cells so any replacement with CD32 variant will only produce non-CCR5 expressive T-cells. There will be no place for HIV to latch on and replicate.

Since the reservoirs exist outside of the marrow a non-CD32 transplant will not stop HIV.

Best case scenario - The half life of CD4+ memory T-cells is 44 months. Without a virological event leronlimab may be able to block all CCR5 receptors, keeping new CD4+ memory T-cells from becoming infected. So every 44 months, under best conditions, half the reservoir ceases to exist. Over a very long period of time leronlimab may effectuate a cure.

ohm20 5/17/2019[/quote]