Replies to post #233796 on Amarin Corp Plc (AMRN)

[IgnoranceIsBliss]

Dmiller — ICER assumes 87% with diabetes have at least one risk factor

And for dudes, being 55 is another risk factor

It’s not that hard to get risk factors — you should look at the list

[MontyBurns92]

You need to have diabetes or heart disease and then two more risk factors.

I think you misspoke. It's the other way around. You must have "established CVD" (whatever that is) OR you could have diabetes plus two risk factors. Here are the risk factors again and I am surprised obesity is not one of them, but I would bet the vast majority of diabetics have two of these.

a. Men ≥55?years of age and women ≥65?years of age
b. Cigarette smoker or stopped smoking within 3 months before Visit 1
c. HTN (BP ≥140?mm Hg systolic OR ≥90?mm Hg diastolic) or on antihypertensive medication
d. HDL-C ≤40?mg/dL for men or ≤50?mg/dL for women
e. hsCRP >3.00?mg/L (0.3?mg/dL)
f. Renal dysfunction: CrCl >30 and <60?mL/min
g. Retinopathy, defined as any of the following: nonproliferative retinopathy, preproliferative retinopathy, proliferative retinopathy, maculopathy, advanced diabetic eye disease, or a history of photocoagulation
h. Micro- or macroalbuminuria. Microalbuminuria is defined as either a positive micral or other strip test (may be obtained from medical records), an albumin/Cr ratio ≥2.5?mg/mmol, or an albumin excretion rate on timed collection ≥20?mg/min all on ≥2 successive occasions. Macroalbuminuria is defined as Albustix or other dipstick evidence of gross proteinuria, an albumin/Cr ratio ≥25?mg/mmol, or an albumin excretion rate on timed collection ≥200?mg/min all on ≥2 successive occasions.
i. ABI <0.9 without symptoms of intermittent claudication (patients with ABI <0.9 with symptoms of intermittent claudication are counted under CV Risk Stratum 1)

[sharinky]

"You need to have diabetes or heart disease and then two more risk factors. I don't believe stress & family history qualify. If your triglycerides are 150 and above, you qualify for on-label. "

That is not true. Look at the label.

VASCEPA is an ethyl ester of eicosapentaenoic acid (EPA) indicated:
• as an adjunct to maximally tolerated statin therapy to reduce the risk of myocardial infarction, stroke, coronary revascularization, and unstable
angina requiring hospitalization in adult patients with elevated triglyceride (TG) levels (≥ 150 mg/dL) and
o established cardiovascular disease or
o diabetes mellitus and 2 or more additional risk factors
for cardiovascular disease. (1)
• as an adjunct to diet to reduce TG levels in adult patients with severe
(≥ 500 mg/dL) hypertriglyceridemia. (1)

[sts66]

I see you were already corrected for mixing up qualifying conditions to get an on label script, won't repeat that - but will add that family history of CVD is absolutely a risk factor, and a big one at that.

[jfmcrr]

You need to have diabetes or heart disease and then two more risk factors. I don't believe stress & family history qualify. If your triglycerides are 150 and above, you qualify for on-label.

If you have a dollar or two of disposable income, getting the script is not beyond reach of many and neither is paying for it. If you get to where you think you qualify, to my mind, you're 3/4 there. You can find a doc or a way. Insurance payment is the remainder. Chocolate syrup and drops on the frosting. Which kinda explains how I got there.