Replies to post #228980 on Amarin Corp Plc (AMRN)

[Atom0aks]

Actually the patent application makes no mentions of Vascepa or AMARIN, it does however mention MOCHIDA, Epadel, and even Epanova....no Vascepa.

Vascepa is only mentioned in clinical trial. If GILD didn’t have a relationship with AMARIN I expect they would use icosapent Ethyl in trial and not Vascepa.

There’s flat out something going on....

BB

Vascepa is found under the "Detailed Description" section of the patent.

Source: http://www.freepatentsonline.com/y2019/0134041.html

[marzan]

BB, the patent you linked in fact mentions Vascepa under Methods of Treatment in so many paragraphs.

http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PG01&s1=16%2F153497&OS=16/153497&RS=16/153497Methods of Treatment

[0045] In some aspects, provided is a method of treating, stabilizing or lessening the severity or progression of a non-alcoholic fatty liver disease (NAFLD), which method comprises administering to a patient in need thereof an ACC inhibitor in combination with a PPAR.alpha. agonist. In some embodiments, provided is a method of treating, stabilizing, or lessening the severity or progression of a non-alcoholic fatty liver disease, wherein the method comprises administering to a patient in need thereof an ACC inhibitor in combination with a PPAR.alpha. agonist, wherein the PPAR.alpha. agonist is selected from the group consisting of aluminum clofibrate, bezafibrate, ciprofibrate, choline fenofibrate, clinofibrate, clofibrate, clofibride, fenofibrate, gemfibrozil, pemafibrate, ronifibrate, simfibrate, an omega-3 fatty acid (e.g., icosapent ethyl (Vascepa.RTM.), or docosahexaenoic acid), pirinixic acid, GW409544, AZ 242, LY518674, NS-220, AVE8134, BMS-711939, aleglitazar, and muraglitzar.

[0046] In some aspects, provided is a method of treating, stabilizing or lessening the severity or progression of a non-alcoholic fatty liver disease (NAFLD), which method comprises administering to a patient in need thereof an ACC inhibitor in combination with fish oil, e.g., icosapent ethyl (Vascepa.RTM.).

[0047] In some aspects, provided herein is a method of treating, stabilizing or lessening the severity or progression of a NAFLD while reducing or eliminating the occurrence or lessening the severity of hypertriglyceridemia, wherein the method comprises administering to a patient in need thereof an ACC inhibitor in combination with a PPAR.alpha. agonist. In some aspects, provided herein is a method of treating, stabilizing or lessening the severity or progression of a NAFLD without substantially increasing the plasma triglyceride levels of the patient, wherein the method comprises administering to a patient in need thereof an ACC inhibitor in combination with a PPAR.alpha. agonist. In some embodiments, the PPAR.alpha. agonist is selected from the group consisting of aluminum clofibrate, bezafibrate, ciprofibrate, choline fenofibrate, clinofibrate, clofibrate, clofibride, fenofibrate, gemfibrozil, pemafibrate, ronifibrate, simfibrate, an omega-3 fatty acid (e.g., icosapent ethyl (Vascepa.RTM.), docosahexaenoic acid, .alpha.-linolenic acid, hexadecatrienoic acid, stearidonic acid, eicosatrienoic acid, eicosatetraenoic acid, eicosapentaenoic acid, heneicosapenaenoic acid, docosapentaenoic acid, tetracosapentaenoic acid, tetracosahexaenoic acid, and the like), pirinixic acid, GW409544, AZ 242, LY518674, NS-220, AVE8134, BMS-711939, aleglitazar, muraglitzar and saroglitazar.