Replies to post #228061 on Amarin Corp Plc (AMRN)

[jessellivermore]

Vascepa and liver problems...

I have no Idea...

":>) JL

[Atom0aks]

JL, do you happen to know why the Vascepa commercial says if you have liver problems to tell your doctor? It’s not one of the few side effects and I was unable to answer. TIA

It is referring to how the drug is cleared by the body and not a side effect of the drug on the liver. Most drugs are metabolized by enzymes in the liver, so oftentimes, patients with liver disease have decreased ability to metabolize drugs and clear them. Hope this helps!

Edit: I'm on my phone so referencing my sources is challenging, but if you want to learn more, the info should be in Vascepas FDA label insert or googling "pharmacokinetics" should give you the answer you're looking for.

[jfmcrr]

do you happen to know why the Vascepa commercial says if you have liver problems to tell your doctor?

I coupla three years ago when I first started to take EPA and spoke to health care professionals about it, I got a "You (We'll) should keep an eye on your liver..." in passing comments similar to the current concern that if you are taking therapeutic amounts of a dietary supplement, you should be aware that it may interact with current medications/uncover a borderline issue. I got the same cautions about "Watch your blood/bleeding..."

It seems like a legacy issue that allows a vague concern to be expressed for the population as a whole, while also allowing that there's someone somewhere to whom this may be important. .