News 
Market Data 
Discover
Replies to post #220824 on Amarin Corp Plc (AMRN)
10/24/19 6:36 AM
10/24/19 6:45 AM
Long-chain n-3 polyunsaturated fatty acids, EPA + DHA, or EPA alone reduce triglycerides by reducing VLDL particle formation and VLDL triglyceride clearance in the circulation. Severe hypertriglyceridemia (>500 mg/dl) should be treated with 4 g of n-3 fatty acids to reduce triglycerides by 20-30%. Lower doses have not been shown to be effective for primary or secondary prevention. The recent REDUCE-IT study demonstrated that persons with high- risk ASCVD or diabetes with one additional vascular risk factor, and triglyceride level of 135-500 mg/dl with well-controlled LDL-C on a statin, who received 4g of icosapent ethyl had a 25% reduction of major CV events that was not related to effect on triglycerides. Icosapent ethyl is a proprietary and highly purified form of EPA. The REDUCE-IT study findings should not be generalized to recommend a dietary supplement with fish oil. It is thought that the value of icosapent ethyl is related to other mechanisms including anti-inflammatory and anti-thrombotic.
